Distonía y CBD

How CBD can help you with Dystonia?

Dystonia is a movement disorder in which muscles contract, resulting in frequent involuntary movements or changes in posture. The condition therefore hinders daily activities, causes social isolation and can be painful for muscle contractions. Also, with this wave of acceptance and new research on cannabis, do we know if CBD can help treat dystonia?

 

Distonía Muscular y cómo tratarla con CBD
Muscular Dystonia and how to treat it with CBD by Laboratorios Canalanza

 

In 1984, a report of a patient with Meige syndrome was published. The patient benefited from treatment with 200 mg CBD. Meige syndrome is a form of dystonia affecting the eyelid and facial muscles.

 

How can CBD help?

 

In a preliminary open-label pilot study, CBD was administered to five patients with dystonic movement disorders. Oral doses of CBD increasing from 100 to 600 mg/day were administered over a 6-week period along with standard medication. The dose-related improvement in dystonia ranged from 20 to 50%. 

 

Aceite de CBD elaborado por Laboratorios Canalanza
CBD oil produced by Laboratorios Canalanza

 

However, side effects of CBD were mild and included hypotension, dry mouth, psychomotor retardation, dizziness and sedation. Finally, in 2 patients with dystonia, with coexisting parkinsonian features, CBD at doses above 300 mg/day exacerbated hypokinesia and resting tremor.

 

Animal studies on CBD

 

In mouse studies, the natural cannabinoid CBD attenuated catalepsy, characterised by muscle rigidity and postural stiffness. Catalepsy caused by the antipsychotic drug haloperidol, by L-nitro-N-arginine (L-NOARG) or by the synthetic cannabinoid WIN55,212-2, which acts similarly to THC.

Furthermore, the researchers noted that “these findings indicate that CBD can attenuate catalepsy caused by different mechanisms through activation of 5-HT1A receptors. It therefore suggests that it may be useful in the treatment of disorders of the striatum”. These disorders include Parkinson’s disease, dystonia and dyskinesia.

 

*Source: ABC.es

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